𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Molecular control of tissue-specific expression at the mouse TNF locus

✍ Scribed by C. Victor Jongeneel; Alexander N. Shakhov; Sergei A. Nedospasov; Jean-Charles Cerottini

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
576 KB
Volume
19
Category
Article
ISSN
0014-2980

No coin nor oath required. For personal study only.

✦ Synopsis

Molecular control of tissue-specific expression at the mouse TNF locus

We have examined the patterns of mRNA accumulation and transcription of the tandemly linked genes for tumor necrosis factor (TNF)-P and TNF-a. In spite of their tandem arrangement and close linkage, the two TNF genes utilize separate promoters. Our results show that, while levels of mRNA correlate with patterns of TNF-a and TNF-fi secretion by lymphocytes and macrophages, the transcriptional levels of the corresponding genes do not. The TNF-a gene is transcribed much more heavily than the TNF-p gene in T lymphocytes, even though the TNF-f3 mRNA is more abundant. Resting T lymphocytes and macrophages, which do not accumulate any TNF mRNA, nevertheless transcribe the TNF-a gene actively. On the other hand, the TNF-fl gene is transcriptionally silent in macrophages. Our results are consistent with a model where tissue specificity is controlled transcriptionally, whereas posttranscriptional events differentially control mRNA abundance.

πŸ“œ SIMILAR VOLUMES

Tissue-specific expression of cre recomb
Tissue-specific expression of cre recombinase from the Pax8 locus
✍ Maxime Bouchard; Abdallah Souabni; Meinrad Busslinger πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 309 KB

## Abstract The transcription factor Pax8 is expressed in the developing thyroid gland, inner ear, kidney, and mid‐hindbrain region. __Pax8__ mutant mice die only postnatally due to a thyroid gland defect. Here we report the generation and expression analysis of a __Pax8__^__cre__^ allele. Cre reco

Tissue-specific expression of Cre recomb
Tissue-specific expression of Cre recombinase from the Tgfb3 locus
✍ Liang-Tung Yang; Wai-Yee Li; Vesa Kaartinen πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 597 KB

## Abstract __Tgfb3__, a member of the TGF‐β superfamily, is tightly regulated, both spatially and temporally, during embryogenesis. Previous mouse knockout studies have demonstrated that __Tgfb3__ is absolutely required for normal palatal fusion and pulmonary development. We have generated a novel

Genetic control of enzyme expression inD
Genetic control of enzyme expression inDrosophila: A locus influencing tissue specificity of aldehyde oxidase
✍ Dickinson, W. J. πŸ“‚ Article πŸ“… 1978 πŸ› John Wiley and Sons 🌐 English βš– 780 KB

## Abstract A natural genetic variant in __Drosophila melanogaster__ with a highly tissue specific effect on the level of an enzyme (aldehyde oxidase) is described. This variant causes overproduction of the enzyme by a factor of 2‐ to 3‐ fold in paragonia (male accessory sex glands) while having no