Molecular connectivity to find β-blockers with low toxicity

✍ Scribed by R. García-Domenech; C. de Gregorio Alapont; J.V. de Julián-Ortiz; J. Gálvez; L. Popa

• Book ID: 104364860
• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 288 KB
• Volume: 7
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(97)00046-2

✦ Synopsis

Molecular connectivity has been used to find new 13-blocker drugs using linear discriminant analysis and connectivity functions with different topological descriptors. Among the selected compounds stands out the probucol and the J3-carotene. Both of them interact with 13 adrenoceptors.