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Molecular Cloning of Steroid 21-Hydroxylase

✍ Scribed by PERRIN C. WHITE; MARIA I. NEW; BO DUPONT


Book ID
118722275
Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
630 KB
Volume
458
Category
Article
ISSN
0890-6564

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Mutations in Steroid 21-Hydroxylase (CYP
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The inherited inability to synthesize cortisol is termed congenital adrenal hyperplasia. More than 90% of cases are caused by 2 I-hydroxylase deficiency. This syndrome is characterized by signs of androgen excess and often mineralocorticoid deficiency. Steroid 2 1-hydroxylase (P450c2 1) is a microso