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Molecular Cloning of Rat SH2-Containing Inositol Phosphatase 2 (SHIP2) and Its Role in the Regulation of Insulin Signaling

✍ Scribed by Hajime Ishihara; Toshiyasu Sasaoka; Hiroyuki Hori; Tsutomu Wada; Hiroki Hirai; Tetsuro Haruta; W.John Langlois; Masashi Kobayashi


Book ID
115583993
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
378 KB
Volume
260
Category
Article
ISSN
0006-291X

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✍ Annemarie Gagnon; Yulia Artemenko; Thet Crapper; Alexander Sorisky πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 266 KB

## Abstract The role of the inositol lipid 5‐phosphatase (SHIP2) in preadipocyte signaling is not known. Although overexpression of SHIP2 inhibited proliferation and ^3^H‐thymidine incorporation in 3T3‐L1 preadipocytes, there was no effect on insulin‐induced adipogenesis. Insulin promoted SHIP2 tyr