Molecular cloning of cat interleukin-4

✍ Scribed by Virgil E. C. J. Schijns; Christel M. H. Wierda; Els J. M. Dam; Thomas W. Vahlenkamp; Marian C. Horzinek

• Publisher: Springer-Verlag
• Year: 1995
• Tongue: English
• Weight: 158 KB
• Volume: 42
• Category: Article
• ISSN: 0093-7711
• DOI: 10.1007/bf00179411

✦ Synopsis

Interleukin-4 (IL-4), a lymphokine produced mainly by activated T cells and mast cells, is a key regulatory molecule in T-helper cell type-2 (Th-2)-driven immune ~ responses that are considered necessary for the elimination 32 97 of extracellular pathogens (Urban et al. 1991; Scott and Kaufman 1991). Mice treated with IL-4 neutralizing anti-z4s48 bodies (Finkelman et al. 1990), as well as mice bearing a 64 defective IL-4 gene (Ktihn et al. 1991), fail to produce IgE ~93 and show reduced serum levels of IgG1. This indicates a 8o 241 pathophysiological role for IL-4 in the generation of certain ~6 disease states, like hyper-IgE syndrome or IgE-mediated 2a9 allergic conditions (Finkelman et al. 1990; Tepper et al. ~12 337