Molecular Cloning of aCandida albicans Gene (SSB1) Coding for a Protein Related to the Hsp70 Family

✍ Scribed by Maneu, Victoria; Cervera, Ana M.; Martinez, Jose P.; Gozalbo, Daniel

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 368 KB
• Volume: 13
• Category: Article
• ISSN: 0749-503X
• DOI: 10.1002/(sici)1097-0061(19970615)13:7<677::aid-yea131>3.0.co;2-6

✦ Synopsis

We have cloned and sequenced a Candida albicans gene (SSB1) encoding a potential member of the heat-shock protein seventy (hsp70) family. The protein encoded by this gene contains 613 amino acids and shows a high degree (85%) of sequence identity to the ssb subfamily (ssb1 and ssb2) of the Saccharomyces cerevisiae hsp70 family. The transcribed mRNA (2.1 kb) is present in similar amounts both in yeast and germ tube cells of C. albicans.