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Molecular cloning and partial nucleotide sequence of an HLA-B27-associated genomic DNA fragment from a patient with ankylosing spondylitis


Book ID
123046699
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
161 KB
Volume
14
Category
Article
ISSN
0198-8859

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Molecular cloning and partial nucleotide
✍ Joseph A. Trapani; Claudia A. Mickelson; Nicholas J. Deacon; David J. Hooker; Ia πŸ“‚ Article πŸ“… 1985 πŸ› Springer-Verlag 🌐 English βš– 441 KB

Insight into the mechanism of involvement of HLA-B27 in ankylosing spondylitis (AS) (Brewerton et al. 1973, Schlosstein et al. 1973) has previously been hampered by the inability to directly examine the HLA-B27 gene and/or contiguous genetic sequences. Accordingly, we investigated the HLA-B27 gene b