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Molecular cloning and identification of murine caspase-8

✍ Scribed by Marc Van de Craen; Geert Van Loo; Wim Declercq; Peter Schotte; Ilse Van den brande; Susanna Mandruzzato; Pierre van der Bruggen; Walter Fiers; Peter Vandenabeele

Book ID
115628865
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
520 KB
Volume
284
Category
Article
ISSN
0022-2836

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Human ICOS (huICOS) is a T cell-specific molecule structurally related to CD28 and CTLA-4 with potent co-stimulatory activities on T cell proliferation, cytokine induction and T cell help for B cells. We have now cloned and characterized murine ICOS (muICOS). muICOS mRNA of 1.5 kb and 3.3 kb encodes