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Molecular Cloning and Domain Structure of Human Myosin-VIIa, the Gene Product Defective in Usher Syndrome 1B

✍ Scribed by Zheng-Yi Chen; Tama Hasson; Philip M. Kelley; Brian J. Schwender; Marc F. Schwartz; Meena Ramakrishnan; William J. Kimberling; Mark S. Mooseker; David P. Corey


Book ID
115613442
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
959 KB
Volume
36
Category
Article
ISSN
0888-7543

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Myosin VIIa, the product of the Usher 1B
✍ Liu, Xinran ;Vansant, Gordon ;Udovichenko, Igor P. ;Wolfrum, Uwe ;Williams, Davi πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 694 KB

Usher syndrome is the most common form of combined deafness and blindness. The gene that is defective in Usher syndrome 1B (USH1B) encodes for an unconventional myosin, myosin VIIa. To understand the cellular function of myosin VIIa and why defects in it lead to USH1B, it is essential to determine t