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Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics

โœ Scribed by Sokoloff, Pierre; Giros, Bruno; Martres, Marie-Pascale; Bouthenet, Marie-Louise; Schwartz, Jean-Charles

Book ID
109765805
Publisher
Nature Publishing Group
Year
1990
Tongue
English
Weight
887 KB
Volume
347
Category
Article
ISSN
0028-0836

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โœฆ Synopsis

A dopamine receptor has been characterized which differs in its pharmacology and signalling system from the D1 or D2 receptor and represents both an autoreceptor and a postsynaptic receptor. The D3 receptor is localized to limbic areas of the brain, which are associated with cognitive, emotional and endocrine functions. It seems to mediate some of the effects of antipsychotic drugs and drugs used against Parkinson's disease, that were previously thought to interact only with D2 receptors.

๐Ÿ“œ SIMILAR VOLUMES

A novel series of arylpiperazines with h
A novel series of arylpiperazines with high affinity and selectivity for the dopamine D3 receptor
โœ P. John Murray; Lee A. Harrison; Martin R. Johnson; Graeme M. Robertson; David I ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 210 KB

A novel series of arylpiperazines has been synthesised which show high affinity for dopamine D 3 receptors. Several of these compounds exhibit ca. 100 fold selectivity for the dopamine D 3 receptor over D 1 , D 2 and D 4 receptors. In vivo studies suggest that 4 (GR103691) may have an atypical antip