Molecular cloning and brain localization of HZF-2?, a new member of the Rev-erb subfamily of orphan nuclear receptors

✍ Scribed by Pe�a-de-Ortiz, Sandra ;Jamieson, Gordon A.

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 664 KB
• Volume: 32
• Category: Article
• ISSN: 0022-3034
• DOI: 10.1002/(sici)1097-4695(199703)32:3<341::aid-neu7>3.0.co;2-7

✦ Synopsis

We have isolated a novel cDNA honatal brain development and remain elevated in the mologous to the family of nuclear hormone receptors adult rat brain. In situ hybridizatio n analyses localwhich we have designated hippocampal zinc fingerized HZF-2 a/b mRNA expression to all hippocampal 2a (HZF-2a). HZF-2a encodes a protein 494 amino subfields. Within the hippocampus heaviest expres sion acids in length and predicted molecular size of 56 was observed within the dentate gyrus. High levels of kD. HZF-2a shares sequence similarities with orphan HZF-2a/b mRNA were also detected in Purkinje cells nuclear receptors related to thyroid hormone and retiand the granular cell layer of the cerebellum. In sumnoic acid receptors. An additional HZF-2 cDNA clone, mary, HZF-2 a/b are novel orphan nuclear receptors HZF-2b, was isolated. HZF-2 b differs from HZF-2 a which may play an important role in hormone-depenin a nine-amino-acid region carboxyl to the DNAdent aspects of developmenta l processes modulating hipbinding domain thought to participat e in enhancing pocampal and cerebellar plasticity. ᭧ 1977 John Wiley & the interaction of nuclear receptors with DNA. North-