Molecular characterization of voltage and cyclic nucleotide-gated potassium channels in kidney
β Scribed by Desir, Gary V
- Book ID
- 118675760
- Publisher
- Nature Publishing Group
- Year
- 1995
- Tongue
- English
- Weight
- 534 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0085-2538
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Endogenous voltage-gated potassium currents were investigated in human embryonic kidney (HEK293) and Chinese hamster ovary (CHO) cells using wholecell voltage clamp recording. Depolarizing voltage steps from Ψ70 mV triggered an outwardly rectified current in nontransfected HEK293 cells. This current
We have cloned a novel voltage-gated K channel, LKv1, in two species of leech. The properties of LKv1 expressed in transiently transfected HEK293 cells is that of a delayed rectifier current. LKv1 may be a major modulator of excitability in leech neurons, since antibody localization studies show tha