Molecular characterization of the Ly-6.2 antigen
β Scribed by Leif C. Andersson; Mikko Hurme; Michael A. Horton; Elizabeth Simpson; Carl G. Gahmberg
- Book ID
- 115812580
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 661 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0008-8749
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## Abstract The E48 antigen is a successfully explored molecular marker for the diagnosis and therapy of HNSCC. The applicability of E48 as an HNSCCβassociated antigen, however, is restricted due to its heterogeneous expression in 30% of tumors; and identification of additional target antigens is t
however. ThB is a 16-18 kd antigen which is not associated on the cell surface with any other "Ly-6" antigens. In addition, independently derived antibodies made to the Ly-6C.2 antigen detect an identical epitope, as do antibodies to Ly-6A.2 and Ly-6B.2. These results imply the existence of a single