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Molecular characterization of ribonucleoprotein antigens bound by antinuclear antibodies. A diagnostic evaluation

✍ Scribed by Dr. L. Matter; K. Schopfer; J. A. Wilhelm; T. Nyffenegger; R. F. Parisot; E. M. De Robertis

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
562 KB
Volume
25
Category
Article
ISSN
0004-3591

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✦ Synopsis

Abstract

The specificity of antinuclear antibodies in sera from 54 patients with various rheumatic diseases was analyzed by immunoprecipitation of ^32^P‐ or ^35^S‐methionine‐labeled HeLa cell extracts. Of 35 sera giving a speckled and/or homogeneous immunofluorescence pattern in rat liver nuclei, 20 contained antibodies to nuclear ribonucleoproteins, which are defined by their ribonucleic acid and protein components. Four sera reacted with a nuclear antigen (Ga) which has not been described so far. Of 19 sera with antinucleolar antibodies, 18 did not react with nuclear or nucleolar ribonucleoproteins. Correlation of these molecularly defined antinuclear antibody specificities with immunofluorescence patterns and rheumatic diseases is discussed.

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