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Molecular characterization of meiotic recombination within the major histocompatibility complex of the mouse: Mapping of crossover sites within theIregion

✍ Scribed by Howard C. Passmore; Joan A. Kobori; Edmund J. Zimmerer; Dominic G. Spinella; Leroy Hood


Publisher
Springer
Year
1987
Tongue
English
Weight
803 KB
Volume
25
Category
Article
ISSN
0006-2928

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Mutants that had lost expression of alleles of one or more HLA loci were isolated with immunoselection after gamma-irradiation of a human lymphoblastoid cell line LCL 721. DNAs from the mutants were digested with restriction endonucleases and analyzed by Southern blotting using probes for class I HL