Molecular characterization of leukocyte adhesion deficiency in six patients
β Scribed by Ann H. Wright; Wendy A. Douglass; G. Malcolm Taylor; Yu-Lung Lau; David Higgins; Kevin A. Davies; S. K. Alex Law
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 793 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0014-2980
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## Heterogeneity in the molecular defect leading to the leukocyte adhesion deficiency* Leukocyte adhesion deficiency (LAD) is a recessive autosomal disease characterized by life-threatening recurrent bacterial infections, by defective functions of leukocytes and by deficient membrane expression of
Communicated by Charles J. Epstein Leukocyte adhesion deficiency (LAD) is an inherited immunodeficiency disorder caused by CD 18 subunit abnormality dependent defective expression of pz integrins on the surface of leukocytes. On analysis of the CD18 molecular defect in a female Japanese patient with
## LFA-1 p-chain synthesis and degradation in patients with leukocyte-adhesive proteins deficiency* The defective membrane expression of the adhesive protein family (LFA-1, Mol and p150,93) on leukocytes from certain patients with recurrent bacterial infections was shown to be secondary to the abs