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Molecular characterization of ataxia telangiectasia T cell clones

โœ Scribed by Marc-Henri Stern; Fangrong Zhang; Gilles Thomas; Claude Griscelli; Alain Aurias

Publisher
Springer
Year
1988
Tongue
English
Weight
539 KB
Volume
81
Category
Article
ISSN
0340-6717

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โœฆ Synopsis

To delimit the 14q32.1 recurrent breakpoint of ataxia telangiectasia clones, we performed an in situ hybridization study with various probes located on the 14q32 band. We thus mapped this breakpoint between the D14S1 and Pi loci. Furthermore, an interstitial duplication including D14S1 and a part of the IgH locus was demonstrated on a t(14;14) clone.

๐Ÿ“œ SIMILAR VOLUMES

Molecular characterization of ataxia tel
Molecular characterization of ataxia telangiectasia T cell clones
โœ Fangrong Zhang; Marc-Henri Stern; Gilles Thomas; Alain Aurias ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Springer ๐ŸŒ English โš– 361 KB

We compared inversions of chromosome 14 in an ataxia telangiectasia clone and in a malignant T cell line (SUP-T1). The R-banding chromosome analysis showed a clear difference between the distal breakpoint of the two inversions. Fine mapping of the distal breakpoint in the ataxia telangiectasia inv(1

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Using in situ chromosomal hybridization we have mapped the gene for the T-cell receptor alpha-chain in three different non-malignant T-cell clones occurring in ataxia telangiectasia. The constant region was translocated in each of the three clones. The variable region remained in its original positi

Apparent ?in situ? clone of cytogenetica
Apparent ?in situ? clone of cytogenetically marked ataxia-telangiectasia lymphocytes
โœ Hook, Ernest B. ;Hatcher, Norma H. ;Calka, Orysia J. ๐Ÿ“‚ Article ๐Ÿ“… 1975 ๐Ÿ› Springer-Verlag โš– 372 KB

Six adjacent metaphases, each with the same cytogenetic aberration of a group D chromosome, most probably a No. 14, were observed in a field of a slide from a 96-hour culture of lymphocytes from an individual with ataxia-telangiectasia (AT). None of the 304 other metaphases examined from this or oth