Molecular Chaperones and Folding Catalysts: Regulation, Cellular Functions and Mechanisms

✍ Scribed by Bernd Bakau

• Publisher: CRC Press
• Year: 1999
• Tongue: English
• Leaves: 784
• Edition: 1
• Category: Library

✦ Synopsis

One of the most intriguing discoveries in molecular biology in the last decade is the existence of an evolutionary conserved and essential system, consisting of molecular chaperones and folding catalysts, which promotes the folding of the proteins in the cell. This text summarizes our current knowledge of the cellular roles, the regulation and the mechanism of action of this system. It has a broad scope, covering cell biological, genetic and biochemical aspects of protein folding in cells from bacteria to man. Particularly appropriate to researchers working in basic and applied aspects of molecular medicine, this volume should also prove useful as an up-to-date reference book and as a textbook for specialized university courses.

✦ Table of Contents

BOOK COVER......Page 1
HALF-TITLE......Page 2
TITLE......Page 4
COPYRIGHT......Page 5
DEDICATION......Page 6
CONTENTS......Page 8
PREFACE......Page 12
CONTRIBUTORS......Page 14
I INTRODUCTION......Page 28
1 ASSISTED PROTEIN FOLDING......Page 30
II REGULATION......Page 38
2 AUTOREGULATION OF THE HEAT SHOCK RESPONSE IN PROCARYOTES......Page 40
3 INDUCIBLE TRANSCRIPTIONAL REGULATION OF HEAT SHOCK GENES: THE STRESS SIGNAL AND THE UNFOLDED PROTEIN RESPONSE......Page 66
4 PROTEIN KINASE CASCADES INVOLVED IN HEAT SHOCK PROTEIN EXPRESSION AND FUNCTION......Page 86
5 THERMOTOLERANCE AND STRESS RESPONSE: POSSIBLE INVOLVEMENT OF KU AUTOANTIGEN......Page 112
III CELLULAR FUNCTIONS......Page 141
6 GENETIC EVIDENCE FOR THE ROLES OF MOLECULAR CHAPERONES IN ESCHERICHIA COLI METABOLISM......Page 143
7 GENETIC DISSECTION OF THE Hsp70 CHAPERONE SYSTEM OF YEAST......Page 182
8 FUNCTIONS IN DEVELOPMENT......Page 207
9 EARLY EVENTS IN THE SYNTHESIS AND MATURATION OF POLYPEPTIDES......Page 223
10 PROTEIN TRANSPORT INTO AND FOLDING WITHIN THE ENDOPLASMIC RETICULUM......Page 253
11 THE ROLE OF MOLECULAR CHAPERONES IN TRANSPORT AND FOLDING OF MITOCHONDRIAL PROTEINS......Page 287
12 PROTEIN IMPORT INTO AND FOLDING WITHIN CHLOROPLASTS......Page 318
13 PROTEIN FOLDING IN THE PERIPLASM OF ESCHERICHIA COLI......Page 337
14 ROLE OF CHAPERONES IN REPLICATION OF BACTERIOPHAGE LAMBDA DNA......Page 352
15 CONTROL OF HORMONE RECEPTOR FUNCTION BY MOLECULAR CHAPERONES AND FOLDING CATALYSTS......Page 373
16 ROLE OF CHAPERONES IN UNCOATING OF CLATHRIN COATED VESICLES......Page 392
17 THE ROLE OF HSP104 IN STRESS TOLERANCE AND PRION MAINTENANCE......Page 411
18 CHAPERONES AND CHARONINS: PROTEIN UNFOLDING ENZYMES AND PROTEOLYSIS......Page 448
IV MECHANISMS......Page 473
19 SPONTANEOUS VERSUS ASSISTED PROTEIN FOLDING......Page 475
20 PROTEIN DISULPHIDE-ISOMERASE: A CATALYST OF THIOL: DISULPHIDE INTERCHANGE AND ASSOCIATED PROTEIN FOLDING......Page 506
21 PEPTIDYL-PROLYL CIS/TRANS ISOMERASES......Page 531
22 THE ATPase CYCLE OF THE GroE MOLECULAR CHAPERONES......Page 564
23 THE RELATIONSHIP BETWEEN CHAPERONIN STRUCTURE AND FUNCTION......Page 597
24 COMPOSITION AND FUNCTION OF THE EUKARYOTIC CYTOSOLIC CHAPERONIN-CONTAINING TCP-1......Page 632
25 STRUCTURE AND MECHANISM OF HSP70 PROTEINS......Page 652
26 THE DnaK CHAPERONE SYSTEM: MECHANISM AND COMPARISON WITH OTHER HSP70 SYSTEMS......Page 690
27 MECHANISMS OF ATP-INDEPENDENT VS. ATP-DEPENDENT CHAPERONES......Page 720
28 STRUCTURE AND FUNCTION OF PERIPLASMIC PAPD-LIKE CHAPERONES INVOLVED IN ASSEMBLY OF BACTERIAL P PILI......Page 749
INDEX......Page 774