Molecular, cellular, and whole animal mechanisms of carcinogenicity

✍ Scribed by Dr. Morris Greenberg

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 170 KB
• Volume: 21
• Category: Article
• ISSN: 0271-3586
• DOI: 10.1002/ajim.4700210203

✦ Synopsis

In this issue, we have a contribution by Walker et al. on the subject of mineral fiber effects at cellular and molecular levels that may relate to the carcinogenic processes. We wish to draw attention to the importance of the approach adopted by the authors in their review of fiber carcinogenesis, as a model for other problem areas in occupational and environmental health. In the occupational and environmental health fields, we are currently beset with a large number of suspected carcinogenic agents, superficially with little in common other than their putative effects.

The following categories of agents are the subject of considerable interest as potentially important occupational or environmental carcinogens: 0 a range of minerals in the true mineralogical fiber form categorized as human carcinogens (there is also concern about the carcinogenic potential of pseudofibrous mineral particles); 0 some 800 chemical agents classified by the International Agency for Research on Cancer to be suspected carcinogens (which list is not deemed to be exhaustive); 0 physical agents such as low-dose ionizing radiation and non-ionizing electromagnetic radiation for which concern has been expressed about the potential for certain waveforms and frequencies to be associated with the induction of cancers in adults and in children.