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Molecular biology of vertebrate learning: Is c-fos a new beginning?

✍ Scribed by L. Kaczmarek

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 565 KB
Volume: 34
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.490340402

No coin nor oath required. For personal study only.

✦ Synopsis

An elevated expression of c-fos nuclear protooncogene (immediate early gene) has been shown repeatedly to correlate with long-term neuronal responses. This paper reviews recent data suggesting that neuronal plasticity, including learning and memory formation, may involve c-fos expression as well. On the basis of biological functions of the Fos protein, well known to be a component of a transcription factor, AP-1, (activator protein 1) a hypothesis suggesting a role of transcription factors in the integration of information during learning processes is proposed.

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