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Molecular Basis of β-Thalassemia in Morocco: Possible Origins of the Molecular Heterogeneity

✍ Scribed by Agouti, Imane; Badens, Catherine; Abouyoub, Ahmed; Levy, Nicolas; Bennani, Mohcine


Book ID
126714379
Publisher
Mary Ann Liebert
Year
2008
Tongue
English
Weight
95 KB
Volume
12
Category
Article
ISSN
1090-6576

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By using oligonucleotide hybridization, restriction endonuclease analysis and direct sequencing of amplified genomic DNA, we have been able to characterize 18 different mutations in the beta-globin genes of 161 beta-thalassemia homozygotes and 107 beta-thalassemia heterozygotes from Turkey (429 beta