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Molecular basis of the T- and L-type Ca2+ currents in canine Purkinje fibres

✍ Scribed by Barbara Rosati; Wen Dun; Masanori Hirose; Penelope A. Boyden; David McKinnon

Book ID
110115411
Publisher
Cambridge University Press
Year
2007
Tongue
English
Weight
462 KB
Volume
579
Category
Article
ISSN
0022-3751

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Block of the cardiac pacemaker current (
Block of the cardiac pacemaker current (If) in the rabbit sino-atrial node and in canine Purkinje fibres by 9-amino-1,2,3,4-tetrahydroacridine
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We have investigated the action of 9-amino-1, 2, 3, 4-tetrahydroacridine (THA) on the pacemaker current If in rabbit sino-atrial node myocytes and in canine Purkinje fibers. THA at concentrations in the range 3-300 microM blocked If in a voltage-independent manner, as revealed by measurements on the