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Molecular basis of inverse agonism in a G protein–coupled receptor

✍ Scribed by Vilardaga, Jean-Pierre; Steinmeyer, Ralf; Harms, Greg S; Lohse, Martin J

Book ID
109914012
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
209 KB
Volume
1
Category
Article
ISSN
1552-4450

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## Abstract It has been recently established that G‐protein‐coupled receptors (GPCRs) can be constitutively active, i.e., they can be active in the absence of an agonist. This activity can be inhibited by so‐called inverse agonists. For a number of GPCRs, such inverse agonists have been developed a