Background. Molecular genetic studies of ovarian cancer have been limited by the inaccessible location of the ovary, the advanced stage of tumors available for analysis, and the lack of a well-defined precursor lesion. However, genetic alterations important in ovarian tumorigenesis have been identif
β¦ LIBER β¦
Molecular basis of endometrial cancer
β Scribed by Andrew Berchuck; Jeff Boyd
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 744 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0008-543X
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## Abstract __Cyclin D1__ is frequently overexpressed in human neoplasias by gene rearrangement and amplification. In addition, Ras, PTEN and Ξ²βcatenin appear to modulate cyclin D1 levels. Since the causes of cyclin D1 overexpression are poorly understood in EC, we investigated whether or not this