Molecular basis of complete complement C4 deficiency in two North-African families with systemic lupus erythematosus
β Scribed by Wu, Y L; Hauptmann, G; Viguier, M; Yu, C Y
- Book ID
- 118675535
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 521 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1466-4879
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Objective. To describe a new kindred with Clq deficiency and to identify the molecular lesions responsible for complete functional Clq deficiency in this and 2 other previously described kindreds. Methods. The A-, B-, and C-chain genes of Clq were amplified by polymerase chain reaction, cloned, and
## Abstract We observed two sisters with lupusβlike syndrome with homozygous C3 deficiencies. A 19βyearβold woman and her 15βyearβold sister developed malar rash, arthralgia, and photosensitivity, but antinuclear antibodies and LE cell preparations were negative. The older sister experienced recurr