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Molecular basis of ADAMTS13 dysfunction in thrombotic thrombocytopenic purpura

✍ Scribed by Minola Manea; Diana Karpman

Publisher
Springer
Year
2009
Tongue
English
Weight
584 KB
Volume
24
Category
Article
ISSN
0931-041X

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ADAMTS13 mutations and polymorphisms in congenital thrombotic thrombocytopenic purpura
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Congenital thrombotic thrombocytopenic purpura (TTP) (also known as Upshaw-Schulman syndrome, USS) is a rare, life-threatening disease characterized by thrombocytopenia and microangiopathic hemolytic anemia, associated with the deficiency of the von Willebrand factor-cleaving protease (ADAMTS13) due