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Molecular basis for the antiandrogen withdrawal syndrome

✍ Scribed by Hiroshi Miyamoto; Mujib M. Rahman; Chawnshang Chang

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
204 KB
Volume
91
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

In patients with prostate cancer who manifest disease progression during combined androgen blockade therapy, discontinuation of antiandrogen treatment might result in prostate‐specific antigen decline, often associated with clinical improvement. The response called antiandrogen withdrawal syndrome is thus acknowledged as a general phenomenon. However, molecular mechanisms responsible for this syndrome are not completely understood. This article outlines the proposed mechanisms, including alterations of androgen receptor gene and its coregulatory proteins and activation of the signal transduction pathway, and the potential therapeutic approaches based on the specific mechanisms. Β© 2003 Wiley‐Liss, Inc.

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