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Molecular basis for multiple forms of LDH-X

✍ Scribed by Goldberg, Erwin

Publisher: John Wiley and Sons
Year: 1973
Tongue: English
Weight: 474 KB
Volume: 186
Category: Article
ISSN: 0022-104X
DOI: 10.1002/jez.1401860306

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✦ Synopsis

Abstract

The guinea pig has three molecular species of LDH‐X which are inhibited by antiserum directed against the C subunit. Only two of these are selectively inhibited by anti‐A polypeptide antiserum. Heterotetramers produced by in vitro dissociation and recombination of isozymes and containing B‐C subunit combinations are selectively inhibited only by the anti‐C antiserum. Therefore, the subunit composition of these multiple forms of LDH‐X are: CCCC; CCCA; CCAA. Similarly, rat testes contain two forms of LDH‐X which can be described as CCCC and CCCA tetramers.

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