Molecular basis for improved anthrax vaccines
β Scribed by Robert N. Brey
- Book ID
- 113417930
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 382 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0169-409X
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Human anthrax vaccines currently licensed in the United States and Western Europe consist of alum-precipitated or aluminum hydroxide-adsorbed supernatant material from fermentor cultures of toxigenic, nonencapsulated strains of Bacillus anthracis. These vaccines have several drawbacks, including the
Anthrax remains a serious threat worldwide as a bioterror agent. A second-generation anthrax vaccine currently under clinical evaluation consists of a recombinant Protective Antigen (rPA) of Bacillus anthracis. We have previously demonstrated that complete protection against inhalational anthrax can