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Molecular basis for differential glycine transporters sensitivity to sanguinarine

✍ Scribed by Frantisek Jursky; Martina Baliova; Andrea Mihalikova


Book ID
116925733
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
902 KB
Volume
212
Category
Article
ISSN
0378-4274

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## Abstract Cellular resistance to the cytotoxic purine analogues 8‐azaguanine (AG) and 6‐thioguanine (TG) is usually mediated by a mutation leading to the loss or reduction in hypoxanthine phosphoribosyltransferase (HPRT) activity. However, stable AG‐resistant variants have often been shown to con