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Molecular assembly of plasminogen and tissue-type plasminogen activator on an evolving fibrin surface

✍ Scribed by Valérie FLEURY; Stéphane LOYAU; H. Roger LIJNEN; Willem NIEUWENHUIZEN; Eduardo ANGLÉS-CANO


Book ID
115130219
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
871 KB
Volume
216
Category
Article
ISSN
1432-1327

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Molecular assembly of plasminogen and tissue-type plasminogen actwator (t-PA) at the surface of fibrin results in the generation of fibrin-bound plasmin and thereby in the dissolution of a clot. This mechanism is triggered by specific interactions of intra-chain surface lysine residues in fibrin wit