✦ LIBER ✦

Molecular and metabolic aspects of lysosomal glycogen

✍ Scribed by Robert Geddes; Pooranalingham Jeyarathan; Jacqueline A. Taylor

Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 620 KB
Volume: 227
Category: Article
ISSN: 0008-6215
DOI: 10.1016/0008-6215(92)85083-c

No coin nor oath required. For personal study only.

✦ Synopsis

The high molecular weight glycogen associated with the lysosomal compartment in glycogen storage disease type VIII is more resistant to degradation by proteinase than normal glycogen. The assembly of large glycogen particles on disulphide-linked protein backbones has been confirmed and the disulphide-reducing nature of the lysosome appears to confer an advantage in the amylolytic degradation of glycogen. Experiments utilising acarbose, a lysosomal (1----4)-alpha-D-glucosidase inhibitor, show that some blood glucose could arise in normal mammals from extra-hepatic tissue, by degradation of the glycogen in the lysosomal compartment.

📜 SIMILAR VOLUMES

Design of expression systems for metabol

Design of expression systems for metabolic engineering: Coordinated synthesis and degradation of glycogen

✍ Neilay Dedhia; Wilfred Chen; James E. Bailey 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 209 KB 👁 1 views

In metabolic engineering, systems which allow coordinated control of two metabolic pathways can be useful. We designed two expression systems and demonstrated their application by coordinating glycogen synthesis and degradation. The first expression vector pMSW2 expressed the glycogen synthesis gene

Metabolic activities and dynamic aspects

Metabolic activities and dynamic aspects of growth in Geotrichum candidum

✍ H. G. Osman; Dr. M. S. Chenouda; H. G. El-Masry 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 191 KB

## Abstract The metabolic activity of __Geotrichum candidum__ was investigated. The chromatographic analysis of the cell pool and of the acid hydrolysate revealed the presence of almost all the amino acids previously detected in other yeasts. The pool pattern was not greatly different from the acid

Some aspects of salicylate distribution

Some aspects of salicylate distribution and metabolism in man

✍ Leo Hollister; Gerhard Levy 📂 Article 📅 1965 🏛 John Wiley and Sons 🌐 English ⚖ 392 KB

Molecular aspects of Huntington's diseas

Molecular aspects of Huntington's disease

✍ Hobart W. Walling; Joseph J. Baldassare; Thomas C. Westfall 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 74 KB

Huntington's disease (HD) is a progressive neurodegenerative disease striking principally medium spiny GABAergic neurons of the caudate nucleus of the basal ganglia. It affects about one in 10,000 individuals and is transmitted in an autosomal dominant fashion. The molecular basis of the disease is

Dynamical aspects of molecular recogniti

Dynamical aspects of molecular recognition

✍ Martin Karplus 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 132 KB

Molecular aspects of calcified tissue

✍ Walton, A. G. 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 English ⚖ 847 KB

## Abstract The detailed relation between primary, secondary, tertiary, and ultrastructure of collagen is presented. Electron micrographs of stained collagen are described in terms of specific peptide location. Data relating to the interaction of polysaccharides, notably chondroitin‐6‐sulfate, and