Molecular and clinical prodrome of Parkinson disease: implications for treatment
β Scribed by Schapira, Anthony H. V.; Tolosa, Eduardo
- Book ID
- 118170446
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 517 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1759-4758
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## Abstract Over the past decade, major progress has been achieved in the identification of genes associated with Parkinson's disease (PD) and parkinsonism. Five genes have now been shown conclusively to play a role in PD susceptibility. Mutations in three of these genes, __PRKN__, __PINK1,__ and _
## Abstract We provide further validation of a Parkinson's disease (PD) home diary and explore implications for practical use in clinical trials. We previously developed and published a home PD diary that includes the categories ASLEEP, __off__, __on__ without dyskinesia, __on__ with nontroublesome