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Molecular and behavioral analysis of the r6/1 huntington′s disease transgenic mouse

✍ Scribed by B. Naver; C. Stub; M. Møller; K. Fenger; A.K. Hansen; L. Hasholt; S.A. Sørensen


Book ID
116786069
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
303 KB
Volume
122
Category
Article
ISSN
0306-4522

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Huntington's disease is a progressive neurodegenerative disease caused by an abnormally expanded (>36) CAG repeat within the ITI5 gene encoding a widely expressed 349-kd protein, huntingtin. The medium spiny neurons of the caudate preferentially degenerate in Huntington's disease, with the presence