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Molecular analysis of the A322D mutation in the GABAA receptor α1-subunit causing juvenile myoclonic epilepsy

✍ Scribed by Klaus Krampfl; Snezana Maljevic; Patrick Cossette; Elke Ziegler; Guy A. Rouleau; Holger Lerche; Johannes Bufler


Book ID
109023978
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
412 KB
Volume
22
Category
Article
ISSN
0953-816X

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Genetic factors play a major role in the etiology of idiopathic generalized epilepsy. However, in most syndromes, especially the common ones, multiple genetic factors seem to be involved. Mutations in K + channel genes have previously found to be associated with epilepsy both in humans and in mice.