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Molecular analysis of HLA-B27 haplotypes in caucasoids frequencies of B27-Cw in jewish and spanish populations

✍ Scribed by Severino González-Roces; Chaim Brautbar; Mercedes Peña; Orlando Dominguez; Eliecer Coto; Victoria Alvarez; Rafael Segal; Carlos López-Larrea

Book ID
119145275
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
584 KB
Volume
41
Category
Article
ISSN
0198-8859

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Hierarchy in the assembly of HLA-B27 and HLA-Cw3 molecules in transgenic mice
✍ Susana Pedrinaci; Julie Hanson; Chella David 📂 Article 📅 1994 🏛 Springer-Verlag 🌐 English ⚖ 841 KB

Cell surface expression of human class I molecules in transgenic mice is dependent upon the available pool of [32-microglobulin ([32m) and the affinity between mouse ~2m and human class I molecules. HLA-B27 and HLA-Cw3 transgenes can be expressed in mouse strains of the H-2 haplotypes b,f, k, and s