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Molecular analysis of an unusual rearrangement between chromosomes 4 and 11 in adult pre–B-cell acute lymphoblastic leukemia

✍ Scribed by Ibtissam Chami; Christine Pérot; Marie-France Portnoı̈; Hélène Jouault; Claire Rieux; Cécile Pautas; Mathieu Kuentz; Michel Tulliez; Dominique Bories


Book ID
114135245
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
468 KB
Volume
133
Category
Article
ISSN
0165-4608

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Molecular analysis of the rearranged gen
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Chromosomal analysis of acute monocytic leukemia cells in a female infant revealed a t(6;11)(q27;q23) translocation. Southern blot analysis with a cDNA probe of the MLL gene at chromosome band 11q23 indicated that the breakpoint was in an 8.3-kb BamHI fragment that contained exons 5-11 of the MLL ge