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Molecular analysis of a new splice variant of the human melanocortin-1 receptor

✍ Scribed by Carina P Tan; Karen Kulju McKee; David H Weinberg; Tanya MacNeil; Oksana C Palyha; Scott D Feighner; Donna L Hreniuk; Lex H.T Van Der Ploeg; Douglas J MacNeil; Andrew D Howard


Book ID
117110828
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
253 KB
Volume
451
Category
Article
ISSN
0014-5793

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The melanocortin 1 receptor, a Gs proteincoupled receptor expressed in epidermal melanocytes, is a major determinant of skin pigmentation and phototype and an important contributor to melanoma risk. MC1R activation stimulates synthesis of black, strongly photoprotective eumelanin pigments. Several M