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Molecular alterations of EGFR and PIK3CA in uterine serous carcinoma

✍ Scribed by Monica Prasad Hayes; Wayne Douglas; Lora Hedrick Ellenson


Book ID
113961929
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
353 KB
Volume
113
Category
Article
ISSN
0090-8258

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## Abstract While the phosphatidylinositol 3‐kinase (PI3K)/AKT signaling pathway is known to be activated in multiple sporadic cancers, the role of this pathway in familial tumors is mostly unknown. We searched for alterations in the catalytic domain of PI3K (__PIK3CA__), PTEN and __KRAS__, all of