Molecular alterations in the tumor suppressor gene WWOX in oral leukoplakias
✍ Scribed by Flávio Juliano Pimenta; Gabriela Tavares Cordeiro; Luiz Gustavo Garcia Santos Pimenta; Michelle Beatriz Viana; Joyce Lopes; Marcus Vinícius Gomez; C. Marcelo Aldaz; Luiz De Marco; Ricardo Santiago Gomez
- Book ID
- 113832944
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 334 KB
- Volume
- 44
- Category
- Article
- ISSN
- 1368-8375
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## Abstract Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of the oral cavity, representing ˜90% of all oral carcinomas and accounting for 3–5% of all malignancies. The __WWOX__ gene (WW‐domain containing oxidoreductase) is a candidate tumor suppressor gene located at 16q
## Abstract Loss of heterozygosity (LOH) on chromosome 3p is a common event in cervical cancer and typically occurs in a dispersed pattern involving several loci. This implies that more than one resident tumor‐suppressor gene is involved in the genesis of these tumors; however, specific targets rem