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Molecular addresses in blood vessels as targets for therapy

✍ Scribed by Mikhail Kolonin; Renata Pasqualini; Wadih Arap

Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
82 KB
Volume
5
Category
Article
ISSN
1367-5931

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✦ Synopsis

We have isolated several organ-and tumor-homing peptides by using in vivo phage display. This technology involves the screening of peptide libraries in a living animal. The peptides that result from such a selection home to specific organs or tissues because they recognize molecular 'addresses', receptors that are differentially expressed in vascular beds. Targeted delivery of chemotherapeutics, pro-apoptotic peptides and cytokines to tumors using these peptides improved therapeutic efficacy in animal models. Translation of this technology into clinical applications will form the basis for targeting therapeutic and imaging agents in the context of cancer and other diseases.

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