✦ LIBER ✦
Molecular abnormality of a unique japanese glucose-6-phosphate dehydrogenase variant (G6PD Kobe) with a greatly increased affinity for galactose-6-phosphate
✍ Scribed by Akira Hirono; Shiro Nakayama; Hisaichi Fujii; Shiro Miwa
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 197 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0361-8609
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✦ Synopsis
Abstract
Systematic molecular analysis of a Japanese class 1 glucose‐6‐phosphate dehydrogenase (GGPD) variant (G6PD Kobe) cONA revealed a unique nucleotide substitution (1318 C to T) in exon 11, which predicts a substitution of leucine for phenylalanine at residue 440. This substitution is located in a region surrounding the putative structural NADP‐binding domain. The markedly abnormal kinetics of glucose‐6‐phosphate (GGP) of GGPD Kobe suggest the interaction between both NADP and G6P binding sites. © 1994 Wiley‐Liss, Inc.