Moisture sorption and permeability characteristics of polymer films: Implications for their use as barrier coatings for solid dosage forms containing hydrolyzable drug substances

✍ Scribed by Mwesigwa, Enosh (author);Basit, Abdul W. (author);Buckton, Graham (author)

• Publisher: John Wiley and Sons Inc.
• Year: 2008
• Tongue: English
• Weight: 297 KB
• Volume: 97
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.21304

✦ Synopsis

Moisture sorption and permeability characteristics of polymer films were studied and their effectiveness to protect a hydrolyzable drug assessed. Cast films were prepared from Eudragit L30 D-55, Eudragit EPO, Opadry AMB and Sepifilm LP dispersions, which were also applied onto tablet cores formulated with aspirin as a model moisture sensitive active ingredient. Sorption studies were undertaken using dynamic vapour sorption, ranging between 0% and 90% RH at 25 degrees C. Cast films exhibited fast equilibration (