✦ LIBER ✦

Modulatory potential of Spirulina fusiformis on carcinogen metabolizing enzymes in Swiss albino mice

✍ Scribed by Anshu Mittal; P. V. Suresh Kumar; S. Banerjee; A. R. Rao; Ashok Kumar

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 46 KB
Volume: 13
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199903)13:2<111::aid-ptr386>3.0.co;2-2

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✦ Synopsis

The modulatory potential of Spirulina fusiformis was observed on the hepatic and extrahepatic carcinogen metabolizing enzymes in Swiss albino mice at a dose of 800 mg/kg b.w. given orally. A significant reduction in the hepatic cytochrome P-450 content was observed in the group treated with Spirulina in comparison with the control group. The hepatic glutathione S-transferase activity was induced significantly by Spirulina treatment. There was no change in the extrahepatic glutathione S-transferase activity after the animals were fed with Spirulina.