Modulator binding protein antagonizes activation of (Ca2+ + Mg2+)-ATPase and Ca2+ transport of red blood cell membranes
✍ Scribed by Larsen, Fred L. ;Raess, Beat U. ;Hinds, Thomas R. ;Vincenzi, Frank F.
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1978
- Tongue
- English
- Weight
- 356 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0091-7419
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✦ Synopsis
Abstract
Red blood cells contain a protein that activates membrane‐bound (Ca^2+^ + Mg^2+^)‐ATPase and Ca^2+^ transport. The red blood cell activator protein is similar to a modulator protein that stimulates cyclic AMP phosphodiesterase. Wang and Desai [Journal of Biological Chemistry 252:4175–4184, 1977] described a modulator‐binding protein that antagonizes the activation of cyclic AMP phosphodiesterase by modulator protein. In the present work, modulator‐binding protein was shown to antagonize the activation of (Ca^2+^ + Mg^2+^)‐ATPase and Ca^2+^ transport by red blood cell activator protein. The results further demonstrate the similarity between the activator protein from human red blood cells and the modulator protein from bovine brain.