Modulations in the biotransformation of tobacco extract andN′-nitrosonornicotine under differential dietary protein status
✍ Scribed by Ammigan, N. ;Nair, U. J. ;Amonkar, A. J. ;Bhide, S. V.
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 611 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0887-2082
No coin nor oath required. For personal study only.
✦ Synopsis
The modulation of the phase I and phase I1 biotransformation enzymes upon treatment with tobacco extract (TE) and N'-nitrosonornicotine (NNN) was investigated using male Sprague-Dawley rats fed differential protein diets. It was observed that the animals fed a low protein diet showed an overall decrease in the basal levels of hepatic and pulmonary phase I and I1 enzymes. TE and NNN significantly decreased the detoxifying system in the low-proteinfed animals. Animals fed 20% protein, however, showed significant increases in glutathione and glutathione S-transferase upon treatment. Furthermore, TE and NNN treatment brought about a significant depletion in the hepatic pool of vitamin A with a concomitant increase in the vitamin C levels.