Modulation of tumoricidal activity, induced in bone-marrow-derived mononuclear phagocytes by interferon γ or Corynebacterium parvum, by interferon β, tumor necrosis factor, prostaglandin E2, and transforming growth factor β
✍ Scribed by Robert Keller; Ruth Keist; Peter H. van der Meide
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- French
- Weight
- 570 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
Among a series of agents, including various interleukins and growth factors, only interferon y (IFNy) and heat-killed Corynebacterium parvurn (CP) organisms were able to elicit, within 24 hr, tumoricidal activity in bone-marrow-derived mononuclear (BMM) phagocytes. In subsequent experiments, the abilities of interferon P (IFNP), tumor necrosis factor a (TNFa), prostaglandin E, (PGE, ), and transforming growth factor f3 (TFGP), alone or in combinations of 2, to modulate tumoricidal activity triggered in BMM phagocytes by lFNy or CP, were compared. In concentrations secreted by macrophages under physiological conditions, these agents proved potent in modulating induction and/or expression of tumoricidal activity. However, their ability to interfere with tumoricidal activity varied considerably, depending on the extent of macrophage differentiation and/or functional responsiveness, the pathway of macrophage activation, the type, concentration and combination of the macrophage secretory molecules, and on whether the agents were present during induction and expression or only during expression of tumoricidal activity. In showing that IFNP and TNFa were mostly enhancing and TGFP mostly suppressive, whereas PGE, suppressed induction but enhanced expression of tumoricidal activity, our findings provide further support for the concept that these macrophage-derived molecules have a key role in autocrine regulation of macrophage functional activities.