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Modulation of the skeletal muscle sodium channel α-subunit by the β1 -subunit

✍ Scribed by Martin Wallner; Lukas Weigl; Pratap Meera; Ilana Lotan

Book ID
118323617
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
557 KB
Volume
336
Category
Article
ISSN
0014-5793

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✍ Christine Ambrose; Shirley Cheng; Bertrand Fontaine; Joseph H. Nadeau; Marcy Mac 📂 Article 📅 1992 🏛 Springer-Verlag 🌐 English ⚖ 782 KB

Recent evidence suggests that the human neuromuscular disorders, hyperkalemic periodic paralysis and paramyotonia congenita, are both caused by genetic defects in the alpha-subunit of the adult skeletal muscle sodium channel, which maps near the growth hormone cluster (GH) on Chromosome (Chr) 17q. I