Modulation of the Release of Adenosine by Glucose and Chemical Hypoxia in Cultured Renal Cells (MDCK Line)
β Scribed by J.L. Reyes; E. Melendez; J. Suarez; M. Rangel; M. Franco; F. Martinez
- Book ID
- 115576362
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 407 KB
- Volume
- 208
- Category
- Article
- ISSN
- 0006-291X
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π SIMILAR VOLUMES
Cyclic AMP plays an important regulatory role in transport activity and proliferation of renal MDCK cells. This observation and the ability of MDCK cells to synthesize prostaglandins provided the impetus to assess the hypothesis that endogenous prostaglandins modulate cyclic AMP concentrations in MD
MDCK kidney epithelial cell cultures exposed to the differentiation inducer hexamethylene bisacetamide (HMBA) for 24 hours exhibited a 50% decrease in transport activity per (Na+, K+)-ATPase molecule (turnover number) but an unchanged number of pump sites (Kennedy and Lever, 1984). Inhibition of pro