Modulation of the peritoneal clearance of liposomal cytosine arabinoside by blank liposomes

✍ Scribed by Sinil Kim; David J. Kim; Stephen B. Howell

• Book ID: 104689124
• Publisher: Springer
• Year: 1987
• Tongue: English
• Weight: 361 KB
• Volume: 19
• Category: Article
• ISSN: 0344-5704
• DOI: 10.1007/bf00261478

✦ Synopsis

Liposomes containing cytosine arabinoside (ara-C) release drug slowly and can be used to maintain a locally high concentration of ara-C in the peritoneal cavity for intracavitary chemotherapy. However, a significant amount of active drug does reach the systemic circulation and contributes to systemic toxicity. We have devised a novel method of decreasing toxicity and increasing intraperitoneal half-life by pretreatment with "blank" liposomes containing no active drug. This technique has resulted in prolongation of intraperitoneal half-life of the liposomal ara-C from 21 h to 165 h, enabling maintenance of a therapeutic drug concentration even at 11 days after initial injection. One hundred percent cures (60-day survival) were achieved with a single-dose therapy begun 1 day after i.p. implantation of 10(6) L1210 leukemia cells.